What is EP Beauty device ?
2024-10-09
Does electroporation (EP) involve punching holes in the face? Electroporation is not really punching on the face. Its role is to instantly open the channel of cell membrane, so that macromolecular substances that cannot enter the cell at ordinary times can enter into the cell, such as some functional ingredients in essence liquid. This technology can improve the problem that essence liquid is not easy to absorb and the absorption is not obvious at ordinary times.
Differences among Three Different Import Modes
This method is manifested in the epidermal layer of the skin, but the introduced ingredients are minimal.
Penetrating beauty ingredients deep into the skin at a rate of 3 million times per second, but not exceeding a certain molecular weight
Has certain limitations
The penetration function far exceeds the previous two import methods
Even large molecule beauty ingredients can be integrated into the skin
This is undoubtedly an efficient instrument naturally designed for the skin
In electroporation (EP)technology, the formation of cell membrane micropores is a complex physical and biochemical process, mainly involving the following key steps:
1. Electric field effect: When a cell is placed in a specific strength of electric field, the electric pulse generates a potential difference on both sides of the cell membrane, causing a change in the distribution of charges on the cell membrane.
2. Membrane potential change: With the increase of electric field strength, the cell membrane potential changes, which promotes changes in the conformation of phospholipid molecules and proteins on the cell membrane, creating conditions for electroporation.
3. Local deformation and rupture: The electric field force causes local protrusions and depressions in the cell membrane. When the electric field strength reaches a threshold, these areas may undergo local rupture, forming hydrophilic pores.
4. Pore formation and expansion: Pore formation begins in the unstable region of phospholipid bilayers, and with the continuous action of the electric field, pores may rapidly expand. This process may involve the rearrangement of phospholipid molecules, as well as the accumulation of water and polar molecules, promoting the stability and expansion of pores.
5. Electrophoretic effect: Under the action of an electric field, charged molecules such as DNA can enter cells through these micropores just like in electrophoresis, because the electric field drives them through the membrane pores.
6. Closure and repair of pores: After the end of the electrical pulse, the natural elasticity of the cell membrane and the rearrangement of phospholipid molecules help restore the integrity of the membrane, and the pores gradually close. Some mechanisms within cells, such as the repositioning of membrane proteins and cell repair processes, also contribute to this process, ensuring cell survival and maintaining function.
The entire process is reversible, as long as the electric field parameters are controlled properly, most cells can recover their structure and function after electroporation, making electroporation an efficient and relatively mild means of gene and drug delivery.
